When ghosts go on a rampage, only four men can save the world. Fired from university research jobs, Drs. Venkman (Murray), Stantz (Aykroyd) and Spengler (Ramis) set up shop as "Ghostbusters," hiring Zeddemore (Hudson) and together ridding Manhattan of bizzare apparitions. But even the spirit exterminators are severly tested when beautiful Dana Barrett (Weaver) and her nerdy neighbor Louis Tully (Moranis) become possessed by demons living in their building. Soon every spook in the city is loose and our heroes face their supreme challenge at a roof-top demonic shrine. If you want your spirits raised, who you gonna call? Ghostbusters!